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Clinical Chemistry 36: 1456-1459, 1990;
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Clinical Chemistry, Vol 36, 1456-1459, Copyright © 1990 by American Association for Clinical Chemistry

Use of zinc protoporphyrin in screening individuals for exposure to lead

WC Zwennis, AC Franssen and MJ Wijnans
Department of Occupational Toxicology, TNO Medical Biological Laboratory, Rijswijk, The Netherlands.

We studied the relation between the concentrations of lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) in a group of 801 men occupationally exposed for more than one year to lead or inorganic lead compounds. Linear regression of PbB on log ZPP provided 95% tolerance intervals for PbB values for a given ZPP value. The intervals we found are too large to warrant the estimation of PbB on the basis of ZPP measurements in health surveillance of lead workers. Instead we propose a procedure in which ZPP can be used as an indicator to decide which individuals exposed to lead need further investigation of PbB in light of existing limit values for PbB. The procedure is applicable only for PbB values of 2.4 mumol/L or more but may reduce considerably the costs for screening individuals or groups of people exposed to lead.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
R. F. Labbe, H. J. Vreman, and D. K. Stevenson
Zinc Protoporphyrin: A Metabolite with a Mission
Clin. Chem., December 1, 1999; 45(12): 2060 - 2072.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
P. Froom, E. Kristal-Boneh, J. Benbassat, R. Ashkanazi, and J. Ribak
Predictive value of determinations of zinc protoporphyrin for increased blood lead concentrations
Clin. Chem., June 1, 1998; 44(6): 1283 - 1288.
[Abstract] [Full Text] [PDF]

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 Arch Pediatr Adolesc MedHome page
P. B. Rolfe, J. F. Marcinak, A. J. Nice, and R. H. Williams
Use of Zinc Protoporphyrin Measured by the Protofluor-Z Hematofluorometer in Screening Children for Elevated Blood Lead Levels
Arch Pediatr Adolesc Med, January 1, 1993; 147(1): 66 - 68.
[Abstract] [PDF]


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