Clinical Chemistry
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Clinical Chemistry 36: 1466-1469, 1990;
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Clinical Chemistry, Vol 36, 1466-1469, Copyright © 1990 by American Association for Clinical Chemistry

Critical appraisal of two methods for determining aluminum in blood samples

CD Hewitt, K Winborne, D Margrey, JR Nicholson, MG Savory, J Savory and MR Wills
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.

We report two methods for determining aluminum concentrations in blood. Method 1, proposed for routine monitoring of patients with chronic renal failure, includes a collection procedure that can be adopted by any renal dialysis unit, with a minimum of sample contamination. Plasma samples are diluted fourfold with HNO3/Triton X-100 matrix modifier. Method 2 is proposed for determining aluminum concentrations in patients with normal renal function, e.g., in drug studies and environmental monitoring. Samples are diluted with an equal volume of Mg(NO3)2 matrix modifier and atomized from a L'vov platform. By either method, analytical recovery of aluminum added to serum ranged between 92% and 105% throughout the linear calibration range. The reference interval (mean +/- SD) for aluminum in 22 healthy subjects by method 2 was 0.044 +/- 0.030 mumol/L.




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Copyright © 1990 by the American Association for Clinical Chemistry.