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Clinical Chemistry 36: 1470-1473, 1990;
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Clinical Chemistry, Vol 36, 1470-1473, Copyright © 1990 by American Association for Clinical Chemistry

Bromide interference: is less really better?

K Emancipator and MH Kroll
National Institutes of Health, Warren G. Magnuson Clinical Center, Bethesda, MD 20892.

Increased serum bromide may result from the ingestion of various drugs and from environmental exposures. Chloride methods that are less susceptible to bromide interference have a clinical disadvantage in that they are less likely to arouse suspicion in cases of bromide toxicity. When there is a clinical suspicion of bromide toxicity, differences among various analyzers in the amount of interference caused by bromide may be exploited to confirm this suspicion and to estimate the concentration of bromide in serum.


The following articles in journals at HighWire Press have cited this article:


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P. Hsieh, Y. Tsan, D. Hung, C. Hsu, Y. Lee, and M. Chang
Bromism caused by mix-formulated analgesic injectables
Human and Experimental Toxicology, December 1, 2007; 26(12): 971 - 973.
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Y.-M. Hung
Bromide intoxication by the combination of bromide-containing over-the-counter drug and dextromethorphan hydrobromide
Human and Experimental Toxicology, August 1, 2003; 22(8): 459 - 461.
[Abstract] [PDF]


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Copyright © 1990 by the American Association for Clinical Chemistry.