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Clinical Chemistry 37: 47-50, 1991;
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Clinical Chemistry, Vol 37, 47-50, Copyright © 1991 by American Association for Clinical Chemistry

Urinary neopterin in patients with systemic lupus erythematosus

L Leohirun, P Thuvasethakul, V Sumethkul, T Pholcharoen and V Boonpucknavig
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Concentrations of neopterin were measured in urine specimens from 35 patients with active and eight with inactive systemic lupus erythematosus (SLE). Compared with those of apparently healthy controls, neopterin concentrations were higher in patients with active disease (P less than 0.001) and with inactive disease (P less than 0.01), those in patients with active disease being significantly higher than those in patients with inactive disease (P less than 0.001). The correlation between the neopterin concentration and evidence of disease activity was good. All of the patients with clinically active SLE had increased neopterin, but for only 37.5% (three of eight) did the neopterin concentration exceed the upper normal limit during clinical remission. The increase in neopterin concentration did not correlate with clinical courses or severity of renal function. Moreover, serial determinations of neopterin in active SLE patients showed a rapid decrease of initially high concentration, paralleling a decline of clinical activity after initiation of medical therapy. Thus, urinary neopterin may be a useful marker for monitoring disease activity in SLE patients.


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Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus
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Copyright © 1991 by the American Association for Clinical Chemistry.