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Clinical Chemistry 37: 1691-1695, 1991;
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Clinical Chemistry, Vol 37, 1691-1695, Copyright © 1991 by American Association for Clinical Chemistry

Radioimmunoassay of interleukin-6 in plasma

AM Teppo, K Metsarinne and F Fyhrquist
IV Department of Medicine, Helsinki University Central Hospital, Finland.

We present a double-antibody radioimmunoassay for determining human interleukin-6 (IL-6) in biological fluids. The detection limit of the assay is 20 ng/L (B0 - 2 SD). Bound radioactivity in the range of 30% to 90% of the B0 counts corresponds to IL-6 concentrations of 100 to 14,000 ng/L. Analytical recovery of IL-6 added to EDTA-treated plasma averaged 25% more than that added to serum. The plasma concentration of IL-6 was therefore approximately 85 ng/L more than the concentration in simultaneously drawn serum. The mean serum concentration of IL-6 in 45 healthy subjects was 83 ng/L (range 20-290 ng/L), in 20 patients with multiple myeloma 303 ng/L, in 20 patients with rheumatoid arthritis 234 ng/L, and in 13 patients with systemic lupus erythematosus 183 ng/L. Markedly increased (greater than 3000 ng/L) concentrations of IL-6 were found in sera of patients with meningococcus meningitis and infectious peritonitis.


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Elevated Circulating Levels of Inflammatory Cytokines in Patients With Abdominal Aortic Aneurysm
Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2843 - 2847.
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