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Clinical Chemistry 37: 1788-1793, 1991;
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Clinical Chemistry, Vol 37, 1788-1793, Copyright © 1991 by American Association for Clinical Chemistry

Polyclonal gammopathy with marked increase in serum viscosity

AO Vladutiu, BM Roach and SM Farahmand
Department of Pathology, SUNY, School of Medicine and Biomedical Sciences, Buffalo.

A 45-year-old man with polyclonal hypergammaglobulinemia (gamma globulins, 102 g/L) had a serum relative viscosity of 13 nu but did not manifest clinical signs of hyperviscosity syndrome (e.g., retinopathy, bleeding diathesis, and neurological alterations), except for fatigue and anorexia. In contrast with other patients with polyclonal hyperviscosity reported so far, this patient did not have detectable rheumatoid factor in serum. Analytical ultracentrifugation of his serum showed aggregates of polyclonal IgG3 of various sizes (between 10 and 36 S). The serum also contained immune complex-like material, as demonstrated by the Raji cell immunoradiometric assay and the C1q solid- phase enzyme immunoassay.


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Copyright © 1991 by the American Association for Clinical Chemistry.