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Clinical Chemistry 37: 1999-2001, 1991;
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Clinical Chemistry, Vol 37, 1999-2001, Copyright © 1991 by American Association for Clinical Chemistry

Determination of intact parathyrin by immunoradiometric assay evaluated in normal children and in patients with various disorders of calcium metabolism

G Saggese, GI Baroncelli and S Bertelloni
Department of Pediatrics, University of Pisa, Italy.

We report the reference values for intact parathyrin (PTH) measured by a two-site immunoradiometric assay (IRMA) during childhood. The study has been carried out in 215 healthy children and adolescents, ages 2.0 to 18.7 years. Some patients with altered mineral homeostasis were also studied to assess the sensitivity of the method in a clinical setting. Mean intact PTH concentrations were 30.8 (SD 9.6) ng/L; the median was 28.5 ng/L. Normal reference values were 16.0-59.0 ng/L (95% confidence interval). The distribution of intact PTH values was nongaussian. We found no significant variations between males and females and no age- related variations. The IRMA used was sufficiently sensitive to detect differences in PTH concentrations between healthy children and patients with hypocalcemia or hypercalcemia.


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Am. J. Clin. Nutr.Home page
G. Barera, S. Beccio, M. C. Proverbio, and S. Mora
Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet
Am. J. Clinical Nutrition, January 1, 2004; 79(1): 148 - 154.
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