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Clinical Chemistry 37: 205-209, 1991;
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Clinical Chemistry, Vol 37, 205-209, Copyright © 1991 by American Association for Clinical Chemistry

Methadone concentrations in plasma and their relationship to drug dosage

K Wolff, M Sanderson, AW Hay and D Raistrick
Department of Chemical Pathology, Old Medical School, University of Leeds, U.K.

We have developed a sensitive HPLC method for measuring methadone in plasma and have used it to establish that there is a linear relationship between plasma concentration and methadone dose over the range of 3-100 mg of methadone per day in a group of 31 addicts. We found a good correlation between dose and plasma concentration (r = 0.89), with the plasma methadone concentration increasing by 0.263 mg/L for every milligram of methadone consumed per kilogram of body weight. Five patients had unexpected high or low concentrations; this finding is discussed.


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