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Clinical Chemistry, Vol 37, 377-386, Copyright © 1991 by American Association for Clinical Chemistry
JD Otvos, EJ Jeyarajah and DW Bennett
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
A new analytical procedure for quantifying plasma lipoproteins by proton nuclear magnetic resonance (NMR) spectroscopy has been developed that potentially offers significant advantages over existing clinical methods used for assessing risk of coronary heart disease. Analysis of a single spectrum of a nonfasting plasma sample, acquired simply and rapidly at moderate magnetic field strength (250 MHz), yields a complete profile of lipoprotein concentrations: chylomicrons and very- low-, low-, and high-density lipoproteins. The method is based on curve- fitting (spectral deconvolution) of the plasma methyl lipid resonance envelope, the amplitude and shape of which depend directly on the amplitudes of the superimposed methyl resonances of the lipoprotein components. A linear least-squares curve-fitting algorithm was developed to efficiently extract the signal amplitudes (concentrations) of the lipoproteins from the plasma spectrum. These signal amplitudes correlate well with lipoprotein concentrations determined by triglyceride and cholesterol measurements.
The following articles in journals at HighWire Press have cited this article:
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J. M. McKenney, M. H. Davidson, C. L. Shear, and J. H. Revkin Efficacy and Safety of Torcetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor, in Individuals With Below-Average High-Density Lipoprotein Cholesterol Levels on a Background of Atorvastatin J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1782 - 1790. [Abstract] [Full Text] [PDF]
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G. J. Blake, J. D. Otvos, N. Rifai, and P. M Ridker Low-Density Lipoprotein Particle Concentration and Size as Determined by Nuclear Magnetic Resonance Spectroscopy as Predictors of Cardiovascular Disease in Women Circulation, October 8, 2002; 106(15): 1930 - 1937. [Abstract] [Full Text] [PDF]
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Y. Fusegawa, K. L. Kelley, J. K. Sawyer, R. N. Shah, and L. L. Rudel Influence of dietary fatty acid composition on the relationship between CETP activity and plasma lipoproteins in monkeys J. Lipid Res., November 1, 2001; 42(11): 1849 - 1857. [Abstract] [Full Text] [PDF]
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 P. Sartipy, G. Camejo, L. Svensson, and E. Hurt-Camejo Phospholipase A2 Modification of Low Density Lipoproteins Forms Small High Density Particles with Increased Affinity for Proteoglycans and Glycosaminoglycans J. Biol. Chem., September 3, 1999; 274(36): 25913 - 25920. [Abstract] [Full Text] [PDF]
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