Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 37: 447-451, 1991;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tetrault, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tetrault, G. A.

Clinical Chemistry, Vol 37, 447-451, Copyright © 1991 by American Association for Clinical Chemistry

Lipase activity in serum measured with Ektachem is often increased in nonpancreatic disorders

GA Tetrault
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.

For patients with symptoms of pancreatitis, measurement of amylase in serum reportedly is more sensitive than that of lipase in acute pancreatitis, whereas lipase reportedly is more specific. However, serum lipase activities exceeding the upper reference limit (URL) have been reported for many patients who did not have pancreatitis. I reviewed the serum lipase and amylase concentrations of 493 consecutive inpatients and emergency department patients for whom both tests were ordered. Serum lipase and amylase activities, determined with an Ektachem 700 analyzer, were less than or equal to URL for 390 patients (83%) and greater than URL for 103. Medical records of 101 of these 103 were reviewed; 18 had acute or chronic relapsing pancreatitis. In this latter group, serum lipase values greater than URL had 100% sensitivity and 84% specificity; those of serum amylase greater than URL had 72% sensitivity and 88% specificity. However, the test combination of serum lipase greater than URL and serum amylase less than or equal to URL also occurred in 84% of the patients in which review of the medical records revealed nonpancreatic gastrointestinal or hepatobiliary disorders as the primary problem (n = 55). Therefore, serum lipase activity measured with the Ektachem assay is also often increased in patients with intra-abdominal disorders that appear to be nonpancreatic.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
Y. E. Taes, H. Louagie, J.-P. Yvergneaux, M. L. De Buyzere, H. De Puydt, J. R. Delanghe, and J. A. Lott
Prolonged Hyperlipasemia Attributable to a Novel Type of Macrolipase
Clin. Chem., December 1, 2000; 46(12): 2008 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
G. Diani, G. Poma, F. Novazzi, S. Zanirato, C. Porta, M. Moroni, G. V. M. d'Eril, and R. Moratti
Increased Serum Lipase with Associated Normoamylasemia in Cancer Patients
Clin. Chem., May 1, 1998; 44(5): 1043 - 1045.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Association for Clinical Chemistry.