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Clinical Chemistry 37: 515-519, 1991;
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Clinical Chemistry, Vol 37, 515-519, Copyright © 1991 by American Association for Clinical Chemistry

Improved sample preparation for accurate determination of low concentrations of lead in whole blood by graphite furnace analysis

BE Jacobson, G Lockitch and G Quigley
Department of Pathology, British Columbia Children's Hospital, Vancouver, Canada.

The effect of low concentrations of lead on pre- and post-natal growth and development is a current concern. We describe a simple method of sample preparation for direct determination of lead in whole blood by Zeeman graphite-furnace atomic absorption spectrometry. This procedure improves analytical precision and accuracy of lead determinations at low concentrations as compared with published furnace data. At blood lead concentrations of 0.25, 1.98, and 3.76 mumol/L, within-run CVs were 3.2%, 1.8%, and 1.4% respectively; between-run CVs were 7.3%, 2.9%, and 2.2%. Accuracy, as demonstrated by analytical recovery, ranged from 99% to 102%. Our reproducibility/accuracy score in the 1989 Quebec interlaboratory comparison program was 96% compared with the target, second best of 66 participating laboratories.


The following articles in journals at HighWire Press have cited this article:


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M. Patriarca, M. Castelli, F. Corsetti, and A. Menditto
Estimate of Uncertainty of Measurement from a Single-Laboratory Validation Study: Application to the Determination of Lead in Blood
Clin. Chem., August 1, 2004; 50(8): 1396 - 1405.
[Abstract] [Full Text] [PDF]

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D.-U. PARK and N.-W. PAIK
Effect on Blood Lead of Airborne Lead Particles Characterized by Size
Ann. Hyg., March 1, 2002; 46(2): 237 - 243.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by the American Association for Clinical Chemistry.