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Clinical Chemistry 37: 695-700, 1991;
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Clinical Chemistry, Vol 37, 695-700, Copyright © 1991 by American Association for Clinical Chemistry

Interferences in current methods for measurements of creatinine

JA Weber and AP van Zanten
Department of Clinical Chemistry, Slotervaart Hospital, Amsterdam, The Netherlands.

We measured the interference of carbonyl compounds, drugs, and other substances in human serum on the determination of creatinine by the two- point, fixed-time kinetic modification of the Jaffe reaction as well as by four enzymatic methods. We added known concentrations of the interfering substances to a solution of creatinine in water. For bilirubin, we used both pooled normal sera with added bilirubin and icteric patient sera. The magnitude of interferences varies widely from method to method. Carbonyl compounds, dopamine, cephalosporines, and bilirubin interfere with the Jaffe reaction. Bilirubin, creatine, dopamine, ascorbic acid, and sarcosine interfere with the enzymatic methods. We conclude that the elimination of interferences in the determination of creatinine has still not been achieved.


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