Clinical Chemistry
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Clinical Chemistry 37: 733-738, 1991;
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Clinical Chemistry, Vol 37, 733-738, Copyright © 1991 by American Association for Clinical Chemistry

Drug screening with EMIT reagents: a quantitative approach to quality control

JC Standefer and RC Backer
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.

We investigated the precision, linearity, accuracy, and stability of quantitative results for five drugs of abuse [amphetamines, benzoylecgonine, opiates, phencyclidine, and the cannabinoid- tetrahydrocannabinol (THC)-9-acid metabolite], analyzed in control specimens by using EMIT d.a.u. reagents (Syva Co.) with a Monarch 2000 analyzer with a nonlinear interpolation curve-fitting algorithm. The within-day and between-days coefficients of variation (CVs) were less than 5% for all drugs except THC-9-acid, which had a CV between 10% and 20%. The drift of control values during a 30-day stability study was less than 10% from target values for three weeks after a single calibration, except for THC-9-acid control values, which were stable for only two to three days. Daily calibration reduced the drift away from target values during the 30-day stability study and produced optimum precision of all drug assays. Mean control values near the National Institute on Drug Abuse cutoff limits were within 10% of their target values.




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Copyright © 1991 by the American Association for Clinical Chemistry.