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Clinical Chemistry 37: 756-758, 1991;
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Clinical Chemistry, Vol 37, 756-758, Copyright © 1991 by American Association for Clinical Chemistry

Detection of toluenediamines in the urine of a patient with polyurethane-covered breast implants

SC Chan, DC Birdsell and CY Gradeen
Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada.

Breast prostheses are implanted for augmentation or during reconstructive surgery. One of the more commonly used prostheses is the polyurethane-sponge-covered silicone gel implant. Some clinicians are concerned about the safety of this product because the polyurethane foam disintegrates in vivo, and its subsequent fate is not known. Polyurethane is a polymer formed by reacting diisocyanates and polyols. This study indicates that the polymer sponge breaks down into its reactive monomers, 2,4- and 2,6-toluenediisocyanate, which are converted into their corresponding diamines. We present evidence of the excretion of the diamine metabolites in the urine of a patient implanted with polyurethane-covered prostheses.


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Copyright © 1991 by the American Association for Clinical Chemistry.