Clinical Chemistry
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Clinical Chemistry 37: 1127-1131, 1991;
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Clinical Chemistry, Vol 37, 1127-1131, Copyright © 1991 by American Association for Clinical Chemistry

Choriogonadotropin-mediated thyrotoxicosis in a man

HJ Cain, PR Pannall, D Kotasek and RJ Norman
Department of Clinical Chemistry, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia.

A 38-year-old man with a metastatic gonadotropin-secreting tumor of unknown primary origin presented with both clinical and biochemical findings of hyperthyroidism in association with markedly increased concentrations of human choriogonadotropin (hCG) in plasma. After chemotherapy, the concentrations of both hCG and free thyroxin decreased and the patient became euthyroid. We discuss the rare occurrence of this presumably hCG-driven hyperthyroidism in men and compare it with the relatively more common eumetabolic hyperthyroidism associated with choriocarcinoma in women.


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S. F. Oosting, E. C. de Haas, T. P. Links, D. de Bruin, W. J. Sluiter, I. J. de Jong, H. J. Hoekstra, D. T. Sleijfer, and J. A. Gietema
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D. Glinoer
The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology
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