Clinical Chemistry
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Clinical Chemistry 37: 1143-1148, 1991;
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Clinical Chemistry, Vol 37, 1143-1148, Copyright © 1991 by American Association for Clinical Chemistry

Bone protein and peptide assays in the diagnosis and management of skeletal disease

LJ Deftos
Department of Medicine, University of California, San Diego.

The measurement in blood of bone proteins is an important adjunct to imaging procedures for clinical assessment of the skeleton. The discovery of new bone proteins and their structural characterization has led to immunochemical procedures of improved sensitivity and specificity for their quantification. An appreciation of the advantages and disadvantages of these evolving methodologies will assist in their clinical application.


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