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Clinical Chemistry 37: 1191-1195, 1991;
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Clinical Chemistry, Vol 37, 1191-1195, Copyright © 1991 by American Association for Clinical Chemistry

Effect of weight loss on serum lipoprotein(a) concentrations in an obese population

JP Corsetti, JA Sterry, JD Sparks, CE Sparks and M Weintraub
Department of Pathology, University of Rochester Medical Center, NY 14642.

To assess the distribution of serum concentrations of the atherogenic lipoprotein(a) [Lp(a)] in an obese population and the possible effects of weight reduction, we determined Lp(a) in 52 white, moderately obese subjects (16 men and 36 women). The subjects were participating in a weight-reduction program of diet, exercise, and behavior modification plus combination anorectic drug therapy (fenfluramine and phentermine). This placebo-controlled, double-blind study lasted 104 weeks. We also determined concentrations of fasting insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein (apo) A-I, low-density lipoprotein cholesterol, and apo B. Results showed the following: a highly skewed, nongaussian distribution of serum Lp(a) values in the obese population, virtually identical to that reported for healthy adults; no clinically significant change in Lp(a) concentrations with weight loss; and further evidence of normalization of insulin, lipid, and lipoprotein concentrations with weight loss.


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Copyright © 1991 by the American Association for Clinical Chemistry.