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Clinical Chemistry 37: 1210-1215, 1991;
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Clinical Chemistry, Vol 37, 1210-1215, Copyright © 1991 by American Association for Clinical Chemistry

Toxicological screening of drugs by microbore high-performance liquid chromatography with photodiode-array detection and ultraviolet spectral library searches

A Turcant, A Premel-Cabic, A Cailleux and P Allain
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.

We use ultraviolet data, acquired with a photodiode-array detector coupled to a reversed-phase liquid-chromatographic system, to identify unknown drugs in plasma samples of acutely poisoned patients. Both retention time and spectra of the peaks obtained with a microbore Hypersil ODS column under gradient elution are compared with a library of approximately 350 compounds. We present our three-year experience with this system, which identifies drugs in less than 1 h, with a high degree of confidence.




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Copyright © 1991 by the American Association for Clinical Chemistry.