Clinical Chemistry
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Clinical Chemistry 37: 1257-1263, 1991;
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Clinical Chemistry, Vol 37, 1257-1263, Copyright © 1991 by American Association for Clinical Chemistry

Multicenter evaluation of new enzyme-linked immunoassays of follitropin and lutropin in serum or plasma

JH Thijssen, WG Wood, AC Kessler, HW Griesser, O Bauer, C Bieglmayer, J Eugui, JL Mirabel, H Gaessler and K Klinga
Department of Endocrinology, University Hospital, Heidelberg/aan, Utrecht, The Netherlands.

Results from a multicenter evaluation of two new enzyme-linked immunosorbent assays [Enzymun-Test for follitropin (FSH) and lutropin (LH)] are presented and compared with results from 11 other commercial immunoassays, radioactive as well as nonradioactive. Enzymun-Test FSH and LH assays are suitable for automated systems and manual applications. The tests were reproducible (CV less than 5%), highly specific, and sensitive enough (less than 0.5 int. unit/L) to measure the hormones directly in almost all patients' samples, except for LH measurements in prepubertal children. We did not find interference by heterophilic antibodies or other factors. A comparison of assays for FSH found very good agreement among all modern two-site assays; competitive immunoassays almost invariably yielded systematically lower results for FSH, probably because of the heterogeneity of the International Reference Preparation (2nd IRP FSH, 78/549). For LH also we found good agreement, with no systematic differences among the various reagents. Guidelines for reference values with the new reagents are given.


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Copyright © 1991 by the American Association for Clinical Chemistry.