Clinical Chemistry
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Clinical Chemistry 37: 1456-1459, 1991;
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Clinical Chemistry, Vol 37, 1456-1459, Copyright © 1991 by American Association for Clinical Chemistry

Detection of two abnormal hemoglobins, Hb Manitoba and Hb G-Coushatta, during analysis of glycohemoglobin (A1c) by high-performance liquid chromatography

SC Wong, M Tesanovic and MC Poon
Department of Laboratory Medicine, Foothills Provincial General Hospital, University of Calgary, Alberta, Canada.

This report concerns the detection of two abnormal hemoglobins (Hb), Hb Manitoba and Hb G Coushatta, during analysis for glycohemoglobin (Hb A1c). Blood samples from two diabetic patients, analyzed for Hb A1c by HPLC, were found to contain additional Hb peaks. The presence of an abnormal Hb was confirmed in both instances by hemoglobinopathy studies. Structural studies determined the two Hb variants to be Hb Manitoba (alpha 2 102 Ser----Arg beta 2) and Hb G-Coushatta (alpha 2 beta 2 22 Glu----Ala). The significance of the presence of an abnormal Hb in Hb A1c analysis is discussed.


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Y Moriwaki, T Yamamoto, Y Shibutani, T Harano, S Takahashi, and T Hada
Abnormal haemoglobins, Hb Takamatsu and Hb G-Szuhu, detected during the analysis of glycated haemoglobin (HbA1C) by high performance liquid chromatography
J. Clin. Pathol., November 1, 2000; 53(11): 854 - 857.
[Abstract] [Full Text] [PDF]

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S. C. Wong and T. C. Aw
Hb E1c as an Indicator for the Presence of Hb AE Phenotype in Diabetic Patients
Clin. Chem., March 1, 1998; 44(3): 660 - 662.
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