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Clinical Chemistry, Vol 38, 150-160, Copyright © 1992 by American Association for Clinical Chemistry
N Rifai, GR Warnick, JR McNamara, JD Belcher, GF Grinstead and ID Frantz Jr
Department of Laboratory Medicine, Children's National Medical Center, Washington, DC 20010.
Current recommendations of the Adult Treatment Panel and the Children and Adolescents Treatment Panel of the National Cholesterol Education Program make the concentration of low-density lipoproteins cholesterol (LDL-C) in serum the basis for the classification and treatment of hypercholesterolemia. Numerous methodologies for the determination of serum LDL-C concentrations, in research and clinical laboratories, have been described. Here, we review the principles, performance, and limitations of major current methodologies for determining LDL-C concentrations. These methods include sequential and density-gradient ultracentrifugation, chromatographic and electrophoretic techniques, and precipitation methods. In addition, the advantages and disadvantages of estimating LDL-C concentration by the Friedewald equation, the most commonly used approach in clinical laboratories, are addressed.
The following articles in journals at HighWire Press have cited this article:
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  E. T. Bairaktari, K. I. Seferiadis, and M. S. Elisaf Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2005; 10(1): 45 - 54. [Abstract] [PDF]
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 M. Nauck, G. R. Warnick, and N. Rifai Methods for Measurement of LDL-Cholesterol: A Critical Assessment of Direct Measurement by Homogeneous Assays versus Calculation Clin. Chem., February 1, 2002; 48(2): 236 - 254. [Abstract] [Full Text] [PDF]
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 R. G. IJzerman, C. D. A. Stehouwer, M. M. van Weissenbruch, E. J. de Geus, and D. I. Boomsma Evidence for Genetic Factors Explaining the Association Between Birth Weight and Low-Density Lipoprotein Cholesterol and Possible Intrauterine Factors Influencing the Association Between Birth Weight and High-Density Lipoprotein Cholesterol: Analysis in Twins J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5479 - 5484. [Abstract] [Full Text] [PDF]
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M. Nauck, M. S. Graziani, D. Bruton, C. Cobbaert, T. G. Cole, F. Lefevre, W. Riesen, P. S. Bachorik, and N. Rifai Analytical and Clinical Performance of a Detergent-based Homogeneous LDL-Cholesterol Assay: A Multicenter Evaluation Clin. Chem., April 1, 2000; 46(4): 506 - 514. [Abstract] [Full Text] [PDF]
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B. Guerci, H. Antebi, L. Meyer, V. Durlach, O. Ziegler, J.-P. Nicolas, L.-G. Alcindor, and P. Drouin Increased Ability of LDL from Normolipidemic Type 2 Diabetic Women to Generate Peroxides Clin. Chem., September 1, 1999; 45(9): 1439 - 1448. [Abstract] [Full Text] [PDF]
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 B. S. Ticho, E. J. Neufeld, J. W. Newburger, N. Harris, A. Baker, and N. Rifai Utility of Direct Measurement of Low-Density Lipoprotein Cholesterol in Dyslipidemic Pediatric Patients Arch Pediatr Adolesc Med, August 1, 1998; 152(8): 787 - 791. [Abstract] [Full Text] [PDF]
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N. Rifai, E. Iannotti, K. DeAngelis, and T. Law Analytical and clinical performance of a homogeneous enzymatic LDL-cholesterol assay compared with the ultracentrifugation-dextran sulfate-Mg2+ method Clin. Chem., June 1, 1998; 44(6): 1242 - 1250. [Abstract] [Full Text] [PDF]
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R. Johnson, P. McNutt, S. MacMahon, and R. Robson Use of the Friedewald Formula to Estimate LDL-Cholesterol in Patients with Chronic Renal Failure on Dialysis Clin. Chem., November 1, 1997; 43(11): 2183 - 2184. [Full Text] [PDF]
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A. Maitra, S. V. Hirany, and I. Jialal Comparison of two assays for measuring LDL cholesterol Clin. Chem., June 1, 1997; 43(6): 1040 - 1047. [Abstract] [Full Text] [PDF]
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