Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 38: 96-100, 1992;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blake, D.
Right arrow Articles by Ratnaike, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blake, D.
Right arrow Articles by Ratnaike, S.

Clinical Chemistry, Vol 38, 96-100, Copyright © 1992 by American Association for Clinical Chemistry

Fecal coproporphyrin isomers in hereditary coproporphyria

D Blake, J McManus, V Cronin and S Ratnaike
Biochemistry Department, Royal Melbourne Hospital, Parkville, Victoria, Australia.

To see whether the fecal coproporphyrin III:coproporphyrin I (CIII:CI) ratio (determined by HPLC) would be suitable for screening patients at risk of hereditary coproporphyria (HC), we compared such ratios with the lymphocyte coproporphyrinogen oxidase (EC 1.3.3.3) activities (COOX) in 38 subjects from one large family and two smaller families with HC. The CIII:CI ratio was normal (less than 1.3) in adults with normal COOX (greater than 180 nmol/g of protein per hour) and high (greater than 2) in those with low COOX. Results were difficult to interpret in six of 10 children, who had borderline or low COOX but normal fecal CIII:CI ratios. Five subjects with low COOX and abnormal fecal CIII:CI ratios had normal fecal total porphyrin, indicating that the latter investigation alone is inadequate for family studies. The sample for determining the fecal CIII:CI ratio is easier to obtain and the assay is technically less demanding than COOX. We found the fecal CIII:CI ratio suitable for investigation of adults in a family study, but its usefulness in children needs to be established.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
S. D. Whatley, N. G. Mason, J. R. Woolf, R. G. Newcombe, G. H. Elder, and M. N. Badminton
Diagnostic Strategies for Autosomal Dominant Acute Porphyrias: Retrospective Analysis of 467 Unrelated Patients Referred for Mutational Analysis of the HMBS, CPOX, or PPOX Gene
Clin. Chem., July 1, 2009; 55(7): 1406 - 1414.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
K. E. Anderson, J. R. Bloomer, H. L. Bonkovsky, J. P. Kushner, C. A. Pierach, N. R. Pimstone, and R. J. Desnick
Recommendations for the Diagnosis and Treatment of the Acute Porphyrias
Ann Intern Med, March 15, 2005; 142(6): 439 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Sandberg and G. H. Elder
Diagnosing Acute Porphyrias
Clin. Chem., May 1, 2004; 50(5): 803 - 805.
[Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A C Deacon and G H Elder
ACP Best Practice No 165: Front line tests for the investigation of suspected porphyria
J. Clin. Pathol., July 1, 2001; 54(7): 500 - 507.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. Rossi
Increased Fecal Porphyrins in Acute Intermittent Porphyria
Clin. Chem., February 1, 1999; 45(2): 281 - 300.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American Association for Clinical Chemistry.