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Clinical Chemistry 38: 2087-2089, 1992;
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Clinical Chemistry, Vol 38, 2087-2089, Copyright © 1992 by American Association for Clinical Chemistry

Serotonin concentrations in plasma and variations during the menstrual cycle

I Hindberg and O Naesh
Department of Clinical Chemistry, Frederiksberg Hospital, Denmark.

We used a specific and sensitive radioenzymatic method to establish a reference interval for the concentration of serotonin in platelet-poor plasma in 98 healthy volunteers (49 men, 49 women). The interval was 0- 11 nmol/L with a median of 2.8 nmol/L. No difference in concentration in relation to sex or age was observed. In a group of eight very old volunteers (ages 86-92 years), however, concentrations were increased. In addition, we monitored the plasma concentrations of serotonin in 20 healthy women (ages 26-45 years) through two menstrual cycles. Periovulatory and premenstrual concentrations were greater than the serotonin concentration at the start of menstruation.


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