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Clinical Chemistry 38: 2117-2120, 1992;
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Clinical Chemistry, Vol 38, 2117-2120, Copyright © 1992 by American Association for Clinical Chemistry

Iohexol in serum determined by capillary electrophoresis

ZK Shihabi and MS Constantinescu
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.

Iohexol, a nonionic compound used as a contrast medium for angiography and as a measure of the glomerular filtration rate, was quantified in serum by capillary electrophoresis. Comparable results were obtained for serum samples deproteinized with acetonitrile or analyzed directly after 50-fold dilution with borate buffer. Serum samples were electrophoresed for 2.6 min at 12 kV in a borate buffer with detection at 254 nm and with 3-isobutyl-1-methylxanthine as internal standard. Acetonitrile deproteinization gave a greater sensitivity than did sample dilution. Between-run CVs were between 4.7% and 6.7%, and within- run CVs were between 2.5 and 3.2%. Analytical recoveries were 95-105%. Results of the method compared well with those by high-performance liquid chromatography (slope 0.96, intercept 0.005 g/L). This method demonstrates the potential of capillary electrophoresis for rapid and simple quantification of small molecules.


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W. E. Braselton, K. J. Stuart, and J. M. Kruger
Measurement of serum iohexol by determination of iodine with inductively coupled plasma–atomic emission spectroscopy
Clin. Chem., August 1, 1997; 43(8): 1429 - 1435.
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Copyright © 1992 by the American Association for Clinical Chemistry.