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Clinical Chemistry 38: 2228-2232, 1992;
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Clinical Chemistry, Vol 38, 2228-2232, Copyright © 1992 by American Association for Clinical Chemistry

Cross-reactivity of anti-digoxin antibodies with digitoxin depends on tracer structure

R Stenzel and B Reckmann
E. Merck, R&D Diagnostics Division, Darmstadt, Germany.

The most common methods for measuring digoxin concentrations in serum are immunoassays. The prerequisite for exact determination of the digoxin value is an antibody that specifically binds digoxin. Because digitoxin differs from digoxin only in the C-12 hydroxy group, it is difficult to obtain anti-digoxin antibodies that do not cross-react with this compound. During the development of a fluorescence polarization immunoassay (FPIA) for digoxin, we investigated digoxin tracers with different structures. We found that in FPIA the digitoxin cross-reactivity of an antibody could be reduced by varying the structure of the tracer molecule.




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Copyright © 1992 by the American Association for Clinical Chemistry.