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Clinical Chemistry 38: 2506-2509, 1992;
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Clinical Chemistry, Vol 38, 2506-2509, Copyright © 1992 by American Association for Clinical Chemistry

The two mRNAs encoding rat intestinal alkaline phosphatase represent two distinct nucleotide sequences

MJ Engle and DH Alpers
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.

Rat duodenal mucosa contains two mRNAs (2.7 and 3.0 kb) encoding intestinal alkaline phosphatase (IAP), but the mechanism for their production has not been clear. By means of the polymerase chain reaction (PCR), we isolated a fragment that identifies a second rat IAP (rIAP-II), differing from the rIAP-I sequence in the coding and 3' untranslated regions and encoding a COOH-terminal sequence predicted to be hydrophilic. By means of probes unique to each sequence, rIAP-I identified the 2.7-kb mRNA, and rIAP-II the 3.0-kb mRNA. The different structures and differential regulation of the mRNAs after fat feeding demonstrate the presence of two rat IAP transcripts.


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Copyright © 1992 by the American Association for Clinical Chemistry.