Clinical Chemistry
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Clinical Chemistry 38: 199-203, 1992;
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Clinical Chemistry, Vol 38, 199-203, Copyright © 1992 by American Association for Clinical Chemistry

Serum erythropoietin concentrations and iron status in patients on chronic hemodialysis

C Seguchi, T Shima, M Misaki, Y Takarada and T Okazaki
Department of Internal Medicine, Yamada Red Cross Hospital, Mie, Japan.

We studied the relationship between serum erythropoietin (EPO) concentration and iron status in 67 patients undergoing chronic hemodialysis. Serum concentrations of EPO were measured by RIA with recombinant human EPO. The geometric mean of the serum EPO concentration was 10.9 int. units/L (mean +/- SD range = 7.8 - 15.3 int. units/L) in hemodialysis patients, considerably lower than that in normal subjects (12.9 int. units/L). We found no significant correlation between concentrations of serum EPO and hemoglobin in hemodialysis patients, but found a significant negative correlation between serum concentrations of EPO and iron in hemodialysis patients. Moreover, we also found a significant positive correlation between the EPO concentration and the unsaturated iron-binding capacity (UIBC) in serum, and a significant negative correlation between the serum concentrations of EPO and ferritin in hemodialysis patients. Several patients who had relatively high EPO concentrations for hemodialysis patients also had low iron concentrations, high UIBC values, and low ferritin concentrations. These findings suggest that iron was utilized even at these EPO concentrations, which were very low for the degree of anemia observed in the hemodialysis patients.


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 J. Am. Soc. Nephrol.Home page
J. KUMAGAI, N. YORIOKA, H. KAWANISHI, M. MORIISHI, Y. KOMIYA, Y. ASAKIMORI, N. TAKAHASHI, and S. TSUCHIYA
Relationship between Erythropoietin and Chronic Heart Failure in Patients on Chronic Hemodialysis
J. Am. Soc. Nephrol., November 1, 1999; 10(11): 2407 - 2411.
[Abstract] [Full Text]


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Copyright © 1992 by the American Association for Clinical Chemistry.