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Clinical Chemistry 38: 411-413, 1992;
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Clinical Chemistry, Vol 38, 411-413, Copyright © 1992 by American Association for Clinical Chemistry

D-mannose as a preservative of glucose in blood samples

AY Chan, CS Ho, TY Chan and R Swaminathan
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.

We studied the changes in blood glucose concentration in blood samples collected in heparinized specimen tubes containing no other preservative, or containing NaF, D-mannose, or a combination of NaF and D-mannose. Blood concentration in samples taken into NaF decreased by 0.40 mmol/L in the first 2 h; thereafter, there was no change. In samples collected into mannose there was a small but significant decrease in blood glucose concentration with time. When samples containing mannose were analyzed immediately after collection, the concentration of glucose was higher than in later analyses, probably because of an exchange of intracellular glucose for extracellular mannose. When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis. We conclude that a combination of D-mannose and NaF may be a better preservative for blood glucose than either compound alone.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
M. Landt
Glyceraldehyde Preserves Glucose Concentrations in Whole Blood Specimens
Clin. Chem., August 1, 2000; 46(8): 1144 - 1149.
[Abstract] [Full Text] [PDF]


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Copyright © 1992 by the American Association for Clinical Chemistry.