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Clinical Chemistry 38: 526-529, 1992;
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Clinical Chemistry, Vol 38, 526-529, Copyright © 1992 by American Association for Clinical Chemistry

Determining zinc coproporphyrin in maternal plasma--a new method for diagnosing amniotic fluid embolism

N Kanayama, T Yamazaki, H Naruse, K Sumimoto, K Horiuchi and T Terao
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.

We measured the concentration of zinc coproporphyrin I (ZnCP-I), a characteristic component of meconium, in maternal plasma by fluorometry after HPLC. We obtained plasma samples from 89 women: 35 at weeks 10-40 of normal pregnancy, 41 shortly after normal delivery, 4 from patients with amniotic fluid embolism (AFE), and 9 from non-AFE patients with intra- or postpartum shock caused by genital bleeding. The plasma ZnCP- I concentration was 97 (SD 83, range 38-240) nmol/L in the AFE patients, 11 (SD 9.2) nmol/L in the non-AFE patients, 12 (SD 7.9) nmol/L during normal pregnancy, and 26 (SD 10) nmol/L shortly after normal delivery. We suggest that measuring ZnCP-I in maternal plasma by fluorometry on HPLC is a rapid, noninvasive, and sensitive method for diagnosing AFE and propose 35 nmol/L as the cutoff value for the ZnCP-I concentration in maternal plasma for the diagnosis of AFE.


The following articles in journals at HighWire Press have cited this article:


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Canadian J. AnesthesiaHome page
B. K. Ray, M. C. Vallejo, M. D. Creinin, K. T. Shannon, G. L. Mandell, B. Kaul, and S. Ramanathan
Amniotic fluid embolism with second trimester pregnancy termination: a case report: [Embolie amniotique lors d'une interruption de grossesse au deuxieme trimestre : expose d'un cas]
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S. Davies
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Can J Anesth, January 1, 2001; 48(1): 88 - 98.
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M. Bannister and S. Davies
Amniotic fluid embolism
Can J Anesth, April 1, 2000; 47(4): 381 - 381.
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