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Clinical Chemistry 38: 553-557, 1992;
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Clinical Chemistry, Vol 38, 553-557, Copyright © 1992 by American Association for Clinical Chemistry

Performance of proficiency survey samples in two immunoradiometric assays of human growth hormone and comparison with patients' samples

PJ Pringle, J Jones, PC Hindmarsh, MA Preece and CG Brook
Kabi International Growth Research Centre, Middlesex Hospital, London, U.K.

The immunoradiometric assay (IRMA) used in our laboratory for the measurement of growth hormone (hGH; somatotropin) performed badly in the national proficiency survey program, the U.K. External Quality Assessment Scheme (EQAS). We compared our assay with another IRMA, which gave similar results for patients' samples and performed adequately in EQAS. The samples from EQAS are collected from patients with polycythemia and fall into two categories: those containing endogenous hGH and those supplemented with pituitary-derived hGH. Analysis of the two groups separately showed that the differences between the two IRMAS were in the measurement of the endogenous hormone. The reason for this appears to be a matrix effect related to the fact that the EQAS serum samples are collected from polycythemic patients.


The following articles in journals at HighWire Press have cited this article:


Home page
 Arch. Dis. Child.Home page
H Mitchell, M T Dattani, V Nanduri, P C Hindmarsh, M A Preece, and C G D Brook
Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency
Arch. Dis. Child., May 1, 1999; 80(5): 443 - 447.
[Abstract] [Full Text]


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Copyright © 1992 by the American Association for Clinical Chemistry.