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Clinical Chemistry 38: 678-680, 1992;
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Clinical Chemistry, Vol 38, 678-680, Copyright © 1992 by American Association for Clinical Chemistry

Patterns of serological markers for cellular immune activation in patients with dilated cardiomyopathy and chronic myocarditis

M Samsonov, D Fuchs, G Reibnegger, JN Belenkov, EL Nassonov and H Wachter
Institute for Clinical Cardiology, All-Union Cardiology Research Center, Moscow, Russia.

We determined serum concentrations of neopterin and beta 2- microglobulin, soluble markers of cellular immune activation, in 27 patients with either dilated cardiomyopathy (DCM) or chronic myocarditis. Neopterin and beta 2-microglobulin concentrations were respectively increased in 2 and 5 of 11 patients with DCM and in 11 and 9 of 16 patients with chronic myocarditis. A higher cardiac functional class (according to the New York Heart Association) was associated with greater neopterin and beta 2-microglobulin concentrations. During follow-up of patients, both neopterin and beta 2-microglobulin concentrations in serum correlated with the course of disease. Additionally, correlations were significant between left ventricular functional tests (end-diastolic volume, end-systolic volume, and ejection fraction) and neopterin and beta 2-microglobulin concentrations. We conclude that measurement of neopterin and beta 2- microglobulin are useful to monitor disease development in patients with myocardial inflammation.


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