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Clinical Chemistry 38: 758-763, 1992;
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Clinical Chemistry, Vol 38, 758-763, Copyright © 1992 by American Association for Clinical Chemistry

Performance of an immunoradiometric assay of erythropoietin and results for specimens from anemic and polycythemic patients

M Andre, A Ferster, M Toppet, P Fondu, M Dratwa and P Bergmann
Laboratory of Clinical Chemistry, Hopital Brugmann-ULB, Brussels, Belgium.

We evaluated a new commercially available two-site immunoradiometric assay (IRMA; BioMerieux 125I-EPO CoatRIA) for erythropoietin (EPO) in human serum. The precision (CV) was 4.1% intra-assay and 8% interassay for a serum pool with an EPO concentration of 17 int. units/L; the detection limit was 0.5 int. unit/L, one order of magnitude lower than by classical radioimmunoassay (RIA), although standardization of IRMA and RIA were similar. Results by both IRMA and RIA are compared for normal subjects, patients with nonrenal noninflammatory anemias, patients with beta-thalassemia major, hemodialysis patients, and patients with primary or secondary polycythemia. Values by IRMA compared well with those by RIA in the upper area of the range; IRMA and RIA values for EPO show parallel expected variations with the degree of anemia. However, because of its greater sensitivity and specificity, we consider the IRMA more appropriate than RIA for investigating patients with sub-normal EPO concentrations.


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F. Corazza, Y. Beguin, P. Bergmann, M. Andre, A. Ferster, C. Devalck, P. Fondu, M. Buyse, and E. Sariban
Anemia in Children With Cancer Is Associated With Decreased Erythropoietic Activity and Not With Inadequate Erythropoietin Production
Blood, September 1, 1998; 92(5): 1793 - 1798.
[Abstract] [Full Text] [PDF]


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Copyright © 1992 by the American Association for Clinical Chemistry.