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Clinical Chemistry, Vol 38, 798-802, Copyright © 1992 by American Association for Clinical Chemistry
L Musset, MC Diemert, F Taibi, L Thi Huong Du, P Cacoub, JM Leger, G Boissy, O Gaillard and J Galli
Laboratoire d'immunochimie, Hopital Pitie-Salpetriere, Paris, France.
We adapted an immunoblotting technique for the immunochemical characterization of cryoglobulins. We first compared the results from 157 samples with results obtained by immunofixation and immunoelectrophoresis and then with clinical observations in 125 cases. Full identification was possible in 98% of the cases by immunoblotting, in 54% by immunofixation, and in 28% by immunoelectrophoresis. Novel microheterogeneity aspects were observed by immunoblotting and immunofixation in 13% and 6% of the cases studied, respectively. Our results confirm the frequency of autoimmune and infectious diseases associated with mixed cryoglobulinemias, whereas a lymphoproliferative syndrome was observed only in cases of cryoglobulinemia with a monoclonal constituent or a microheterogeneity aspect, which was not always revealed by immunofixation or immunoelectrophoresis. The pathophysiological importance and classification of microheterogeneity aspects is not clear. These observations justify using a sensitive and specific method for identifying cryoglobulins, even when present at low concentrations, and call for long-term studies of these patients.
The following articles in journals at HighWire Press have cited this article:
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 M. Prasad, G. K. Buller, C. I. Mena, and A. N. Sofair Sum of the Parts N. Engl. J. Med., December 7, 2006; 355(23): 2468 - 2473. [Full Text] [PDF]
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O. Hermine, F. Lefrere, J.-P. Bronowicki, X. Mariette, K. Jondeau, V. Eclache-Saudreau, B. Delmas, F. Valensi, P. Cacoub, C. Brechot, et al. Regression of Splenic Lymphoma with Villous Lymphocytes after Treatment of Hepatitis C Virus Infection N. Engl. J. Med., July 11, 2002; 347(2): 89 - 94. [Abstract] [Full Text] [PDF]
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 O Lidove, P Cacoub, T Maisonobe, J Servan, V Thibault, J-C Piette, and J-M Leger Hepatitis C virus infection with peripheral neuropathy is not always associated with cryoglobulinaemia Ann Rheum Dis, March 1, 2001; 60(3): 290 - 292. [Abstract] [Full Text] [PDF]
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V. AGNELLO Mixed cryoglobulinaemia after hepatitis C virus: more and less ambiguity Ann Rheum Dis, December 1, 1998; 57(12): 701 - 702. [Full Text]
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E. Santagostino, M. Colombo, D. Cultraro, M. Muca-Perja, A. Gringeri, and P.M. Mannucci High Prevalence of Serum Cryoglobulins in Multitransfused Hemophilic Patients With Chronic Hepatitis C Blood, July 15, 1998; 92(2): 516 - 519. [Abstract] [Full Text] [PDF]
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P. Cacoub, N. Boukli, P. Hausfater, A. Garbarg-Chenon, P. Ghillani, V. Thibault, L. Musset, J. M. Huraux, and J.-C. Piette Parvovirus B19 infection, hepatitis C virus infection, and mixed cryoglobulinaemia Ann Rheum Dis, July 1, 1998; 57(7): 422 - 424. [Abstract] [Full Text]
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M TRENDELENBURG and J A SCHIFFERLI Cryoglobulins are not essential Ann Rheum Dis, January 1, 1998; 57(1): 3 - 5. [Full Text]
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R. Misiani, P. Bellavita, D. Fenili, P. Cacoub, F. Lunel, L. Musset, P. Opolon, J.-C. Piette, C. Werner, H. I. Joller-Jemelka, et al. Hepatitis C Virus and Cryoglobulinemia N. Engl. J. Med., April 15, 1993; 328(15): 1121 - 1124. [Full Text]
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