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Clinical Chemistry 38: 1340-1342, 1992;
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Clinical Chemistry, Vol 38, 1340-1342, Copyright © 1992 by American Association for Clinical Chemistry

Changes in alkaline phosphatase and 5'-nucleotidase multiple forms after surgical management of biliary obstruction

FJ Novo and JC Tutor
Laboratorio Central, Hospital General de Galicia, Santiago de Compostela, Spain.

Serial measurements of alkaline phosphatase and 5'-nucleotidase multiple forms in two patients undergoing surgical procedures to release biliary obstruction suggested an inverse relationship between high-M(r) isoforms and serum bile acids concentrations. Furthermore, the study of several groups of patients with cholestatic disorders confirmed this inverse correlation. Mechanisms responsible for these observations are discussed.




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Copyright © 1992 by the American Association for Clinical Chemistry.