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Clinical Chemistry 38: 1437-1439, 1992;
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Clinical Chemistry, Vol 38, 1437-1439, Copyright © 1992 by American Association for Clinical Chemistry

A multicenter evaluation of lipid profiling with a compact analyzer (Miles Clinistat)

RW Hardy, RH Ng, RE Hill, S Walker, KM Sparks, S Kent, C Lakes, CE Hiar, R Valdes Jr and BE Statland
Department of Pathology and Laboratory Medicine, Washington University Medical Center, Jewish Hospital of St. Louis, MO 63110.

We evaluated the Clinistat Analyzer (Miles Inc., Diagnostics Division, Elkhart, IN) for measuring cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol at three medical centers. The system, based on multilayer film technology, uses precalibrated, dry film reagent disks. Ten microliters of serum is applied to the dry film reagent disk in the test procedure. For HDL-cholesterol measurement, serum is pretreated by precipitation with phosphotungstic acid and magnesium chloride. Total precision (CVs) of each of the three assays was less than or equal to 5%. The assay ranges were linear and satisfactory for clinical use. Patients' results compared well with established methods. No significant interferences were found with hemolysis, icterus, and lipemia.




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Copyright © 1992 by the American Association for Clinical Chemistry.