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Clinical Chemistry 38: 1658-1664, 1992;
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Clinical Chemistry, Vol 38, 1658-1664, Copyright © 1992 by American Association for Clinical Chemistry

Simultaneous patient-side measurement of hemoglobin, glucose, and cholesterol in finger-stick blood

B Sterling, T Kiang, K Subramanian, M Saltman, W Smart, M Tsay, J Sugarman, D Patel, D Monger and D Martin
Biotrack, Ciba Corning Diagnostics, Mountain View, CA 94043.

We describe a multianalyte assay system for patient-side use comprising single-use plastic cartridges and a small monitor. Hemoglobin, glucose, and cholesterol can be simultaneously measured in 3 min in an unmeasured volume of blood. The sample is drawn by capillary action into four channels for delivery to assay-specific stacks containing a set of closely apposed layers. The distal layer is a membrane that acts as the optical surface for reflectance optics. For glucose and cholesterol assays, erythrocytes are removed by a fibrous filter layer and oxidase-peroxidase chemical reactions contained in the optical membrane generate a colored product. For hemoglobin measurement, blood is lysed by detergent contained in a porous disk. The amount of color reaching the optical membrane is measured by fiber optics. To ensure fail-safe operation, sensors verify sample sufficiency and degree of hemolysis. The assays perform comparably with laboratory methods.




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Copyright © 1992 by the American Association for Clinical Chemistry.