Clinical Chemistry
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Clinical Chemistry 39: 131-134, 1993;
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Clinical Chemistry, Vol 39, 131-134, Copyright © 1993 by American Association for Clinical Chemistry

Biochemical markers for detecting bone metastases in patients with breast cancer

L Moro, C Gazzarrini, D Crivellari, E Galligioni, R Talamini and B de Bernard
Dipartimento di Biochimica, Universita degli Studi di Trieste, Italy.

A study was carried out to assess the best use of biochemical bone markers to exclude metastases in patients with breast cancer. Urinary galactosyl-hydroxylysine and serum alkaline phosphatase were used to monitor bone resorption and deposition, respectively. Hydroxyproline was also measured. In a selected population of patients, possibly affected by metastases on the basis of scintigraphic examination, which is highly sensitive but poorly specific, we assessed the efficiency of the markers by a double statistical analysis. In this group, the only marker able to predict metastases was galactosyl-hydroxylysine.


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