Clinical Chemistry
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Clinical Chemistry 39: 147-150, 1993;
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Clinical Chemistry, Vol 39, 147-150, Copyright © 1993 by American Association for Clinical Chemistry

C-reactive protein and its cytokine mediators in intensive-care patients

J Sheldon, P Riches, R Gooding, N Soni and JR Hobbs
Department of Immunology, Charing Cross and Westminster Medical School, London, UK.

C-reactive protein (CRP) is an acute-phase protein produced by the liver during bacterial infections and inflammation. The cytokines interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF) are widely reported to induce synthesis of CRP by hepatocytes both in vitro and in vivo. We investigated the relation between CRP and its cytokine mediators in 64 critically ill patients during their treatment in the intensive-care unit. Plasma CRP and IL-6 concentrations were significantly lower in patients without any evidence of infection than in those with clinical infection; plasma IL-1 beta concentrations showed no significant difference between any of the groups, but plasma TNF concentrations were lower in patients with evidence of infection. Significant correlation was seen between plasma concentrations of CRP and IL-6 when the latter was measured by bioassay; however, IL-6 showed, at best, only a 50% predictive value for a change in CRP concentration.


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E.S. Kilpatrick, B.G. Keevil, C. Jagger, R.J. Spooner, and M. Small
Determinants of raised C-reactive protein concentration in type 1 diabetes
QJM, April 1, 2000; 93(4): 231 - 236.
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Copyright © 1993 by the American Association for Clinical Chemistry.