Clinical Chemistry
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Clinical Chemistry 39: 152-154, 1993;
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Clinical Chemistry, Vol 39, 152-154, Copyright © 1993 by American Association for Clinical Chemistry

Early diagnosis of ectopic arginine vasopressin secretion [published erratum appears in Clin Chem 1995 Aug;41(8 Pt 1):1207]

S Coyle, MD Penney, PW Masters and BE Walker
Department of Chemical Pathology, St. James's University Hospital, Leeds, UK.

We describe a patient who presented with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) 2 months before clinical evidence of bronchogenic malignancy. Because of the potential for the ectopic production of atrial natriuretic peptide (ANP) to mimic SIADH, both hormones were measured in this hyponatremic patient to seek a possible marker of tumor activity. A hypertonic saline infusion at presentation revealed excessive osmotically decoupled secretion of arginine vasopressin but a normal ANP response.


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F. Wu and Q. Wu
Corin-Mediated Processing of Pro-Atrial Natriuretic Peptide in Human Small Cell Lung Cancer Cells
Cancer Res., December 1, 2003; 63(23): 8318 - 8322.
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