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Clinical Chemistry 39: 45-47, 1993;
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Clinical Chemistry, Vol 39, 45-47, Copyright © 1993 by American Association for Clinical Chemistry

Biliary and urinary neopterin concentrations in monitoring liver- allograft recipients

A Hausen, C Aichberger, A Konigsrainer, G Weiss, R Margreiter and H Wachter
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

Biliary neopterin concentrations were measured daily in nine liver- transplant recipients during the early post-transplant period (on average, 25 days). Concentrations increased strongly during rejection episodes and decreased quickly after successful antirejection therapy. Contrary to the changes of urinary neopterin, cytomegalovirus infection and hepatitis were not associated with an increase in biliary neopterin concentrations. Therefore, measurement of neopterin in bile fluid and in urine may aid in distinguishing rejection from infectious complications in liver-allograft recipients.




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Copyright © 1993 by the American Association for Clinical Chemistry.