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Clinical Chemistry 39: 72-75, 1993;
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Clinical Chemistry, Vol 39, 72-75, Copyright © 1993 by American Association for Clinical Chemistry

Differences in serum potassium concentrations in normal men in different geographic locations

MM Reidenberg, ZP Gu, B Lorenzo, E Coutinho, C Athayde, J Frick, F Alvarez, V Brache and EE Emuveyan
Department of Pharmacology and Medicine, Cornell University Medical College, New York, NY 10021.

Hypokalemia has been associated with the taking of gossypol, a potential oral antifertility drug for men. Because the frequency of this response differed in different parts of the world, this study was done to learn if "normal" serum [K+] also differed. [K+] was measured by flame photometry in serum from apparently normal men from Austria (n = 30), China (53), Brazil (100), the Dominican Republic (38), and the US (103), and in plasma from Nigerian men (82). The mean (SD) for [K+] in Chinese men, 3.82 (0.27) mmol/L, was lower than that in Brazilians [4.06 (0.29) mmol/L], Austrians [4.14 (0.44) mmol/L], Dominicans [4.37 (0.33) mmol/L], or Americans [4.38 (0.37) mmol/L]. Apparently there are regional differences in average serum [K+], with men in China having lower serum [K+] than men elsewhere. This may predispose them to hypokalemia.


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J. Qiu, L. R. Levin, J. Buck, and M. M. Reidenberg
Different Pathways of Cell Killing by Gossypol Enantiomers
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