Clinical Chemistry
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Clinical Chemistry 39: 87-92, 1993;
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Clinical Chemistry, Vol 39, 87-92, Copyright © 1993 by American Association for Clinical Chemistry

Breath acetone analyzer: diagnostic tool to monitor dietary fat loss

SK Kundu, JA Bruzek, R Nair and AM Judilla
Abbott Laboratories, Department 90J, Abbott Park, IL 60064.

Acetone, a metabolite of fat catabolism, is produced in excessive amounts in subjects on restricted-calorie weight-loss programs. Breath acetone measurements are useful as a motivational tool during dieting and for monitoring the effectiveness of weight-loss programs. We have developed a simple, easy-to-read method that quantifies the amount of acetone in a defined volume of exhaled breath after trapping the sample in a gas-analyzer column. The concentration of acetone, as measured by the length of a blue color zone in the analyzer column, correlates with results obtained by gas chromatography. Using the breath acetone analyzer to quantify breath acetone concentrations of dieting subjects, we established a correlation between breath acetone concentration and rate of fat loss (slope 52.2 nmol/L per gram per day, intercept 15.3 nmol/L, n = 78, r = 0.81). We also discussed the possibility of using breath acetone in diabetes management.


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 J. Appl. Physiol.Home page
J. C. Anderson, W. J. E. Lamm, and M. P. Hlastala
Measuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver
J Appl Physiol, March 1, 2006; 100(3): 880 - 889.
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Copyright © 1993 by the American Association for Clinical Chemistry.