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Clinical Chemistry 39: 2413-2418, 1993;
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Clinical Chemistry, Vol 39, 2413-2418, Copyright © 1993 by American Association for Clinical Chemistry

Circadian pharmacodynamics of anticancer therapies

WJ Hrushesky
Stratton V.A. Medical Center, Albany, NY 12208.

Circadian variation in drug metabolism and tissue sensitivity to drugs affects their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced by administering antineoplastic agents at carefully selected times of the day. Here I briefly review molecular, cellular, and organismic time-keeping mechanisms as well as cytokinetic, pharmacokinetic, and pharmacodynamic data, which support the predictable and exploitable nonlinear dynamic relation between dose and effect that occurs each day.




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Copyright © 1993 by the American Association for Clinical Chemistry.