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Clinical Chemistry 39: 2492-2494, 1993;
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Clinical Chemistry, Vol 39, 2492-2494, Copyright © 1993 by American Association for Clinical Chemistry

Antibodies to casein kinase II in sera of patients with mixed connective tissue disease: evaluation with recombinant proteins

C Wiemann, L Bodenbach and W Pyerin
Biochemical Cell Physiology, German Cancer Research Center, Heidelberg.

In this study we determined the prevalence of autoantibodies against casein kinase II (CKII) in patients positive for anti-70K marker antibodies, which is indicative of mixed connective tissue disease. An anti-CKII ELISA was established with the use of bacterially expressed recombinant CKII proteins. Eight out of 52 anti-70K-positive sera (15%) were positive for anti-CKII antibodies, which recognized preferentially the CKII alpha subunit. All control sera (n = 52) were anti-CKII negative. Thus, the occurrence of anti-CKII antibodies may be of value for differential diagnosis.




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Copyright © 1993 by the American Association for Clinical Chemistry.