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Clinical Chemistry 39: 209-212, 1993;
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Clinical Chemistry, Vol 39, 209-212, Copyright © 1993 by American Association for Clinical Chemistry

Coronary artery disease risk predicted by plasma concentrations of high- density lipoprotein cholesterol, apolipoprotein AI, apolipoprotein B, and lipoprotein(a) in a general Chinese population

JH Wu, JT Kao, MS Wen and D Wu
Department of Microbiology and Immunology, Chang-Gung Medical College, Tao-Yuan, Taiwan.

We measured lipid and lipoprotein concentrations in blood samples from control subjects and patients with coronary artery disease (CAD) in Taiwan. We found significant differences (P < 0.01) in the concentrations of high-density lipoprotein cholesterol (HDLC), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB), and lipoprotein(a) [Lp(a)]. Concentrations of HDLC < 350 mg/L, ApoAI < 900 mg/L, ApoB > 800 mg/L, and Lp(a) > 200 mg/L occurred, respectively, 2.8, 5.2, 1.7, and 2.3 times more frequently in the patients than in the control group. If one considers HDLC at < 350 mg/L, ApoAI at < 900 mg/L, ApoB at > 800 mg/L, and Lp(a) at > 200 mg/L as separate risk factors for CAD, the ratio of individual patients to control subjects having 4, 3, 2, 1, or 0 risk factors was [symbol: see text] 9.4, 2.1, 0.2, 0.2, respectively. Individuals displaying three or more risk factors were found 15 times more frequently in the CAD group than in the control group. These risk factors may be used clinically for the prediction and prevention of CAD in the general population.


The following articles in journals at HighWire Press have cited this article:


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 Arterioscler. Thromb. Vasc. Bio.Home page
P. N. Hopkins, L. L. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams
Lipoprotein(a) Interactions With Lipid and Nonlipid Risk Factors in Early Familial Coronary Artery Disease
Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2783 - 2792.
[Abstract] [Full Text]


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Copyright © 1993 by the American Association for Clinical Chemistry.