Clinical Chemistry
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Clinical Chemistry 39: 325-332, 1993;
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Clinical Chemistry, Vol 39, 325-332, Copyright © 1993 by American Association for Clinical Chemistry

Assessment of the role of G proteins and inositol phosphate production in the action of gonadotropin-releasing hormone

BE Hawes and PM Conn
Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242-1109.

The first step in gonadotropin-releasing hormone (GnRH) action involves the binding of GnRH to a plasma membrane receptor. Calcium has been implicated as a second messenger molecule. More recently, it has been suggested that the products of phosphoinositide metabolism may act as a second messenger for GnRH-stimulated release of luteinizing hormone (LH). To be considered a second messenger, however, a candidate molecule must meet three requirements: in the second messenger's presence, (a) GnRH should stimulate increased production of inositol phosphate; (b) inositol phosphate production, stimulated by any means, should provoke LH release; and (c) inhibition of inositol phosphate production should block GnRH-stimulated release of LH.


The following articles in journals at HighWire Press have cited this article:


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 EndocrinologyHome page
M. S. Roberson, T. Zhang, H. L. Li, and J. M. Mulvaney
Activation of the p38 Mitogen-Activated Protein Kinase Pathway by Gonadotropin-Releasing Hormone
Endocrinology, March 1, 1999; 140(3): 1310 - 1318.
[Abstract] [Full Text]


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Copyright © 1993 by the American Association for Clinical Chemistry.