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Clinical Chemistry 39: 353-355, 1993;
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Clinical Chemistry, Vol 39, 353-355, Copyright © 1993 by American Association for Clinical Chemistry

c-myc oncogene expression in estrogen-dependent and -independent breast cancer

RP Shiu, PH Watson and D Dubik
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

We demonstrate that c-myc gene expression is essential for growth of breast cancer cells. It also plays an important role in the progression of human breast cancer. c-myc gene amplification may be important for cancer cell invasion, but perhaps not essential for nodal metastasis. We also provide compelling evidence that the c-myc oncogene is an estrogen target gene in hormone-responsive breast cancer. Hormonal progression of breast cancer could be brought about by the enhanced expression of the c-myc gene, with gene amplification and enhanced c- myc mRNA stability being two major mechanisms involved.


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I. V. Chernukhin, S. Shamsuddin, A. F. Robinson, A. F. Carne, A. Paul, A. I. El-Kady, V. V. Lobanenkov, and E. M. Klenova
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Copyright © 1993 by the American Association for Clinical Chemistry.