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Clinical Chemistry 39: 356-361, 1993;
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Clinical Chemistry, Vol 39, 356-361, Copyright © 1993 by American Association for Clinical Chemistry

Programming events in the regulation of cell proliferation and death

R Berges and JT Isaacs
Johns Hopkins Oncology Center, Department of Urology, Baltimore, MD.

In developing new and more successful therapies for preventing and treating cancer, it is critical to understand what normally regulates cell proliferation and cell death and what are the specific dysfunctions associated with these regulations in individual cancers. Here we review the programmed series of molecular, cellular, and biochemical events required for a cell's entrance and progression through the proliferative vs death processes as a starting point for such approaches to new therapies.


The following articles in journals at HighWire Press have cited this article:


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 J. Biol. Chem.Home page
S. Tawfic, M. O. J. Olson, and K. Ahmed
Role of Protein Phosphorylation in Post-translational Regulation of Protein B23 during Programmed Cell Death in the Prostate Gland
J. Biol. Chem., September 8, 1995; 270(36): 21009 - 21015.
[Abstract] [Full Text] [PDF]


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Copyright © 1993 by the American Association for Clinical Chemistry.