Clinical Chemistry, Vol 39, 420-423, Copyright © 1993 by American Association for Clinical Chemistry

Behavior of tumor markers CA19.9, CA195, CAM43, CA242, and TPS in the diagnosis and follow-up of pancreatic cancer

G Banfi, A Zerbi, S Pastori, D Parolini, V Di Carlo and P Bonini
Laboratorio Analisi, Istituto Scientifico H. S. Raffaele, Milano, Italy.

We compared the recently proposed tumor markers CA195, CA242, and CAM43 with a widely used antigen, CA19.9, and a circulating marker of cellular proliferation, TPS, to define their specificity, sensitivity, and cost-benefit ratio. The tumor markers were measured in 41 pancreatic carcinoma patients and in two control groups, the first comprising 19 patients with benign pancreatic diseases, the second comprising 41 healthy blood donors. Sensitivities were 79% for CA19.9, 57% for CA242, 60% for CAM43, 76% for CA195, and 98% for TPS. Specificities calculated for the group with pancreatic diseases were 60% for CA19.9, 84% for CA242, 95% for CAM43, 53% for CA195, and 22% for TPS. Specificities for the blood donor group were 100% for CA19.9, 93% for CA242, 98% for CAM43, 85% for CA195, and 88% for TPS. Positive values for the tumor markers appeared from second stage (Hermreck classification). Metastases, invasion of lymph nodes, and coupling of cancer-associated antigens did not significantly modify marker sensitivity. In pancreatic carcinoma, CA19.9 showed good sensitivity (79%) and high specificity (60-100%). In view of their own advantages (e.g., high specificity of CAM43, high sensitivity of TPS in recurrences) and limits (e.g., low sensitivity of CAM43, very low sensitivity of TPS), the other markers could be used alone or with CA19.9. Two pairs of tumor markers showed high similarity in our study: CA19.9 and CA195, and CAM43 and CA242.

The following articles in journals at HighWire Press have cited this article:

				A Harlozinska-Szmyrka and M Strutynska-Karpinska The diagnostic dilemmas in discrimination between pancreatic carcinoma and chronic pancreatitis Gut, March 1, 2004; 53(3): 469 - 470. [Full Text] [PDF]

				G. Banfi, P. Parma, and M. Pontillo Stability of Tumor Markers CA 19.9, CA 125, and CA 15.3 in Serum Obtained from Plain Tubes and Tubes Containing Thixotropic Gel Separator Clin. Chem., December 1, 1997; 43(12): 2430 - 2431. [Full Text]