Clinical Chemistry
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Clinical Chemistry 39: 540-543, 1993;
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Clinical Chemistry, Vol 39, 540-543, Copyright © 1993 by American Association for Clinical Chemistry

High-molecular-mass alkaline phosphatase as a tumor marker for colorectal cancer: comparison of two test methods

JS Wei, NC Chung, LL Wei, WF Tzeng, TZ Liu and JY Wang
Laboratory of Clinical Enzymology, School of Medical Technology, Chang Gung Medical College, Taiwan, R.O.C.

We measured high-molecular-mass alkaline phosphatase (HiMwALP) in serum samples from patients with colorectal cancer by polyacrylamide gel electrophoresis (PAGE) and by column chromatography on diethylaminoethyl (DEAE)-cellulose. Determination of carcinoembryonic antigen (CEA) by an enzyme immunoassay, a frequently used cancer assessment method, was used for comparison. We studied patients with primary colorectal cancer (n = 72), using others with hemorrhoids (n = 38) for a comparison group. HiMwALP activities twice those of pooled normal sera were adopted as cutoff values. The diagnostic sensitivity of the PAGE method for 72 colorectal cancer patients was 63% vs 36% for the DEAE method and 50% for the CEA method. The diagnostic specificities of the PAGE, DEAE, and CEA methods were 89%, 79%, and 95%, respectively. Using both HiMwALP (PAGE method) and CEA for the detection of primary colorectal cancer increased the sensitivity to 72% but decreased specificity to 87%.


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 Cancer Epidemiol. Biomarkers Prev.Home page
S. Hundt, U. Haug, and H. Brenner
Blood Markers for Early Detection of Colorectal Cancer: A Systematic Review
Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1935 - 1953.
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Copyright © 1993 by the American Association for Clinical Chemistry.